Biologists report new evidence for evolutionary change recorded in both the fossil record and the genomes (or genetic blueprints) of living organisms, providing fresh support for Charles Darwin's theory of evolution.The researchers were able to correlate the progressive loss of enamel in the fossil record with a simultaneous molecular decay of a gene, called the enamelin gene, that is involved in enamel formation in mammals.
"Mammals without enamel are descended from ancestral forms that had teeth with enamel," Springer said. "We predicted that enamel-specific genes such as enamelin would show evidence in living organisms of molecular decay because these genes are vestigial and no longer necessary for survival."
Using modern gene sequencing technology, Meredith discovered mutations in the enamelin gene that disrupt how the enamelin protein is coded, resulting in obliteration of the genetic blueprint for the enamelin protein.
Darwin argued that all organisms are descended from one or a few organisms and that natural selection drives evolutionary change. The fossil record demonstrates that the first mammals had teeth with enamel. Mammals without enamel therefore must have descended from mammals with enamel-covered teeth.
"The molecular counterpart to vestigial organs is pseudogenes that are descended from formerly functional genes," Springer explained. "In our research we clearly see the parallel evolution of enamel loss in the fossil record and the molecular decay of the enamelin gene into a pseudogene in representatives of four different orders of mammals that have lost enamel." link