Wednesday, June 11, 2008

Unraveling The Woolly Mammoth Genome

Intraspecific phylogenetic analysis of Siberian woolly mammoths using complete mitochondrial genomes. 2008. M. Thomas et al. PNAS published June 9, 2008. [An open access article]


Art © Frank Frazetta
A large genetic study of the extinct woolly mammoth has revealed that the species was not one large homogenous group, as scientists previously had assumed, and that it did not have much genetic diversity.
From the press release:

The population was split into two groups, then one of the groups died out 45,000 years ago, long before the first humans began to appear in the region. This discovery is particularly interesting because it rules out human hunting as a contributing factor, leaving climate change and disease as the most probable causes of extinction.

The research marks the first time scientists have dissected the structure of an entire population of extinct mammal by using the complete mitochondrial genome -- all the DNA that makes up all the genes found in the mitochondria structures within cells.

The scientists analyzed the genes in hair obtained from individual woolly mammoths -- an extinct species of elephant adapted to living in the cold environment of the northern hemisphere. The bodies of these mammoths were found throughout a wide swathe of northern Siberia. Their dates of death span roughly 47,000 years, ranging from about 13,000 years ago to about 60,000 years ago.

Another important finding for understanding the extinction processes is that the individuals in each of the two woolly-mammoth groups were related very closely to one another. "This low genetic divergence is surprising because the woolly mammoth had an extraordinarily wide range: from Western Europe, to the Bering Strait in Siberia, to Northern America," Miller said.

The study also suggests a genetic divergence of the two woolly-mammoth groups more than 1-million years ago, which is one quarter the genetic distance that separates Indian and African elephants and woolly mammoths. The diversity of the two woolly-mammoth populations was as low centuries ago as it is now in the very small populations of Asian elephants living in southern India.